Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134866 | 0.83 | LRRK2 (0.50) | RETPOLBMEN1KMT2ANPC1 | |
| SCHEMBL14448881 | 0.82 | PLK4 (0.69) | RETKDRMEN1KMT2APDGFRB | |
| SCHEMBL5476084 | 0.82 | PLK4 (0.69) | RETKDRMEN1KMT2APDGFRB | |
| SCHEMBL5476091 | 0.82 | PLK4 (0.69) | RETKDRMEN1KMT2APDGFRB | |
| SCHEMBL14519128 | 0.81 | MDM2 (0.56) | RETPDPK1KDRPOLBERBB2 | |
| SCHEMBL16543016 | 0.79 | MEN1 (0.76) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1300710 | 0.79 | TLK2 (0.65) | RETPDPK1KDRPOLBMEN1 | |
| SCHEMBL1300713 | 0.79 | TLK2 (0.65) | RETPDPK1KDRPOLBMEN1 | |
| SCHEMBL6389814 | 0.79 | RET (0.56) | RETPDPK1KDRMEN1KMT2A | |
| SCHEMBL6389812 | 0.79 | RET (0.56) | RETPDPK1KDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574094-B | Indolone derivatives and pharmaceutical use thereof | 成都大学 | 2022-07-01 | — | — | CN | disclosed |