Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 13/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372141 | 1.00 | CFTR (0.67) | CFTRPIK3CAPDE3BPDE3AIRAK4 | |
| SCHEMBL2371893 | 0.87 | CFTR (0.67) | CFTRPIK3CAPDE3BPDE3A | |
| SCHEMBL14783071 | 0.83 | CFTR (0.65) | CFTR | |
| SCHEMBL2372266 | 0.80 | CFTR (1.00) | CFTR | |
| SCHEMBL22791295 | 0.80 | CFTR (0.82) | CFTR | |
| SCHEMBL29699240 | 0.80 | CFTR (1.00) | CFTR | |
| SCHEMBL2371662 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL22791468 | 0.79 | CFTR (0.82) | CFTR | |
| SCHEMBL29699293 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL14783118 | 0.77 | CFTR (0.51) | CFTRPIK3CAPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |