Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | HPGD | P15428 | 6/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | CASP3 | P42574 | 3/20 | 0.73 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.73 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | CASP6 | P55212 | 1/20 | 0.67 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914044 | 1.00 | MAPT (0.73) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL914357 | 0.87 | MAPT (0.74) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL913664 | 0.85 | MAPT (0.71) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL914596 | 0.83 | MAPT (0.77) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL913332 | 0.83 | MAPT (0.72) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL912737 | 0.83 | SMN1; SMN2 (1.00) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL913600 | 0.80 | SMN1; SMN2 (1.00) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL914037 | 0.78 | SMN1; SMN2 (0.77) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL20545354 | 0.77 | SMN1; SMN2 (1.00) | MAPTALDH1A1HPGDKDM4ECASP3 | |
| SCHEMBL912689 | 0.77 | SMN1; SMN2 (1.00) | MAPTALDH1A1HPGDKDM4ECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114615984-B | Benzoxazinone compounds as dual KLK5/7 inhibitors | 分子皮肤治疗公司 | 2025-02-07 | — | — | CN | disclosed |
| EP-4037687-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | Molecular Skin Therapeutics, Inc. (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114615984-A | Benzoxazinone compounds as KLK5/7 dual inhibitors | 分子皮肤治疗公司 | 2022-06-10 | — | — | CN | disclosed |