Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663686 | 0.91 | MAPT (0.46) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL2209628 | 0.88 | MAPT (0.52) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL15663770 | 0.86 | MAPT (0.49) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL2207808 | 0.86 | KDR (0.47) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL2212027 | 0.85 | MAPT (0.46) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL2210186 | 0.84 | MAPT (0.46) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL15663950 | 0.84 | MAPT (0.48) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL15663349 | 0.84 | MAPT (0.48) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL15663540 | 0.84 | FGFR2 (0.41) | KDRMAPTLMNAENPP3MEN1 | |
| SCHEMBL2210397 | 0.83 | MAPT (0.52) | KDRMAPTLMNAENPP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776857-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2010-08-17 | — | — | US | claimed |
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |