Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301580 | 1.00 | BACE1 (0.79) | BACE1CYP2D6 | |
| SCHEMBL12301374 | 0.93 | BACE1 (0.79) | BACE1 | |
| SCHEMBL298635 | 0.93 | BACE1 (0.79) | BACE1 | |
| SCHEMBL13028270 | 0.89 | BACE1 (0.73) | BACE1 | |
| SCHEMBL287454 | 0.89 | BACE1 (0.68) | BACE1 | |
| SCHEMBL7940225 | 0.89 | BACE1 (0.68) | BACE1 | |
| SCHEMBL12301583 | 0.89 | BACE1 (0.68) | BACE1 | |
| SCHEMBL298636 | 0.88 | BACE1 (0.71) | BACE1 | |
| SCHEMBL12301579 | 0.88 | BACE1 (1.00) | BACE1 | |
| SCHEMBL7940954 | 0.88 | BACE1 (0.83) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427437-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | claimed |
| US-8461160-B2 | Dihydropyrimidinones | HOFFMANN-LA ROCHE, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2427437-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |