Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 16/20 | 0.71 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.71 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.71 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29704240 | 1.00 | PBRM1 (0.71) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL31748599 | 0.91 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL22776314 | 0.91 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30796276 | 0.91 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29704224 | 0.90 | PBRM1 (0.58) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29704302 | 0.88 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30797014 | 0.86 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30797042 | 0.86 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL22777059 | 0.85 | SMARCA2 (0.58) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29704310 | 0.85 | SMARCA2 (0.47) | PBRM1SMARCA2SMARCA4PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259144-A1 | SMARCA DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |