Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19966495 | 1.00 | HSD17B10 (0.39) | HSD17B10DYRK1APDE1APDE1BPDE1C | |
| SCHEMBL18885373 | 0.80 | CYP1A2 (0.36) | DYRK1APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL16663602 | 0.79 | KDM4E (0.34) | PDE1APDE1BPDE1CKDM4EKMT2A | |
| SCHEMBL19542265 | 0.79 | PDE1A (0.34) | PDE1APDE1BPDE1CKDM4EHPGD | |
| SCHEMBL22419377 | 0.77 | FGFR1 (0.36) | PDE1APDE1BPDE1CKDM4E | |
| SCHEMBL16821681 | 0.77 | SLC6A2 (0.35) | HDAC8HTTKMT2A | |
| SCHEMBL22179790 | 0.77 | SLC6A2 (0.35) | HDAC8HTTKMT2A | |
| SCHEMBL22419371 | 0.76 | PDE1A (0.38) | PDE1APDE1BPDE1CKDM4EHDAC8 | |
| SCHEMBL15333094 | 0.76 | HSD17B10 (0.46) | HSD17B10DYRK1ASMN1; SMN2KDM4EHTT | |
| SCHEMBL29377303 | 0.76 | HSD17B10 (0.46) | HSD17B10DYRK1ASMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159745-A1 | GCN2 MODULATING COMPOUNDS AND USES THEREOF | HIBERCELL, INC. (US) | 2022-07-28 | — | — | WO | disclosed |