Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22553277 | 1.00 | PIK3CG (0.46) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL22553248 | 0.94 | PIK3CG (0.45) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| Trifluoroacetic Acid SCHEMBL22553060 | 0.93 | PIK3CG (0.45) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| Trifluoroacetic Acid SCHEMBL29709207 | 0.93 | PIK3CG (0.45) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| Trifluoroacetic Acid SCHEMBL22553180 | 0.89 | PIK3CG (0.43) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| Trifluoroacetic Acid SCHEMBL29709312 | 0.89 | PIK3CG (0.43) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL22553166 | 0.87 | PIK3CG (0.62) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL22553063 | 0.84 | PIK3CG (0.42) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL22553304 | 0.82 | PIK3CG (0.63) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL29709317 | 0.82 | PIK3CG (0.63) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306079-B2 | 3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors | INCYTE CORPORATION (US) | 2022-04-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306079-B2 | 3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors | PIK3CG, PIK3CD, PIK3CA | PIK3CG 1/4885PIK3CA 3/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.