Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297095 | 1.00 | HDAC1 (0.50) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL296351 | 0.93 | HDAC1 (0.48) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL296352 | 0.93 | HDAC1 (0.48) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL211458 | 0.87 | HDAC1 (0.60) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL211459 | 0.87 | HDAC1 (0.60) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL1040569 | 0.86 | HDAC1 (0.46) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL299833 | 0.86 | HDAC1 (0.46) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL4209055 | 0.81 | HDAC1 (0.73) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL4209044 | 0.81 | HDAC1 (0.73) | HDAC1KCNH2HDAC6HDAC3HDAC8 | |
| SCHEMBL211394 | 0.80 | HDAC1 (0.61) | HDAC1KCNH2HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969401-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2015-03-03 | — | — | US | disclosed |
| EP-1725528-B1 | SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2013-05-29 | — | — | EP | disclosed |
| EP-1928826-B1 | SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS | 4SC AG (DE) | 2013-04-24 | — | — | EP | disclosed |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | ALTANA PHARMA AG (DE) | 2013-03-28 | — | — | US | disclosed |
| US-8399505-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8232297-B2 | Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles | 4SC AG (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8188138-B2 | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | 4SC AG (DE) | 2012-05-29 | — | — | US | disclosed |
| EP-1928872-B1 | NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC | 4SC AG (DE) | 2012-03-14 | — | — | EP | disclosed |
| US-8067615-B2 | Sulphonylpyrroles | 4SC AG (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | MAIER THOMAS | 2011-07-07 | — | — | US | disclosed |
| EP-2272827-A1 | Sulphonylpyrroles as hdac inhibitors | 4SC AG (DE) | 2011-01-12 | — | — | EP | disclosed |
| US-7842820-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20100261761-A1 | Novel Sulfonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20100261721-A1 | Novel Sulphonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | NYCOMED GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | NYCOMED GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20070184979-A1 | Novel sulfonylpyrroles | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | HDAC1 1/4885KCNH2 2684/4885HDAC6 8/4885 |
| US-20070184979-A1 | Novel sulfonylpyrroles | HDAC1, HDAC4, HDAC3 | HDAC1 1/4885KCNH2 3120/4885HDAC6 8/4885 |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | HDAC1, HDAC3, HDAC2 | HDAC1 1/4885KCNH2 1929/4885HDAC6 7/4885 |
| US-20100261761-A1 | Novel Sulfonylpyrroles | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885KCNH2 836/4885HDAC6 7/4885 |
| US-20100261721-A1 | Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | HDAC1 1/4885KCNH2 1929/4885HDAC6 7/4885 |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC2 | HDAC1 1/4885KCNH2 1349/4885HDAC6 5/4885 |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885KCNH2 836/4885HDAC6 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.