Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.80 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16336391 | 1.00 | BTK (0.80) | BTKCDC7MKNK1MKNK2CHEK1 | |
| SCHEMBL16336907 | 0.89 | BTK (1.00) | BTKCDC7MKNK1MKNK2CHEK1 | |
| SCHEMBL29709514 | 0.89 | BTK (1.00) | BTKCDC7CHEK1KCNH2 | |
| SCHEMBL16337806 | 0.89 | BTK (1.00) | BTKCDC7CHEK1KCNH2 | |
| SCHEMBL29709606 | 0.87 | BTK (1.00) | BTKCDC7 | |
| SCHEMBL16336553 | 0.87 | BTK (1.00) | BTKCDC7 | |
| SCHEMBL16337199 | 0.82 | BTK (0.67) | BTKMKNK1MKNK2 | |
| SCHEMBL16338291 | 0.81 | BTK (1.00) | BTKCDC7CHEK1KCNH2 | |
| SCHEMBL16336020 | 0.80 | BTK (0.67) | BTKCDC7MKNK1MKNK2 | |
| SCHEMBL16337712 | 0.79 | BTK (0.65) | BTKCDC7MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |