Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.48 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25624401 | 0.86 | PLK1 (0.60) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626388 | 0.74 | PLK1 (0.45) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25623875 | 0.74 | PLK1 (0.77) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25624403 | 0.74 | PLK1 (0.72) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626472 | 0.73 | PLK1 (0.69) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626473 | 0.70 | PLK1 (0.78) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626474 | 0.70 | PLK1 (0.80) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626402 | 0.70 | PLK1 (0.34) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL3504604 | 0.68 | PLK1 (0.84) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL30777921 | 0.68 | PLK1 (0.80) | PLK1PLK3PLK2FLT3NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022143576-A1 | PYRAZOLOQUINAZOLINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 恒元生物医药科技(苏州)有限公司 | 2022-07-07 | — | — | WO | disclosed |