Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF1 | Q13422 | 5/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.64 |
| ▸ | IKZF2 | Q9UKS7 | 13/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23306213 | 1.00 | IKZF1 (0.68) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24856663 | 0.96 | CSNK1A1 (0.69) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24856637 | 0.93 | IKZF2 (0.66) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24856612 | 0.91 | IKZF1 (0.64) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL31021063 | 0.90 | IKZF1 (0.74) | IKZF1IKZF2 | |
| SCHEMBL20765782 | 0.90 | IKZF1 (0.74) | IKZF1IKZF2 | |
| SCHEMBL24856634 | 0.90 | IKZF1 (0.64) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24319970 | 0.88 | IKZF2 (0.63) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24856621 | 0.88 | IKZF1 (0.64) | IKZF1CSNK1A1CRBNIKZF2 | |
| SCHEMBL24856706 | 0.88 | IKZF2 (0.65) | IKZF1CSNK1A1CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051386-A1 | SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2022-09-07 | — | — | EP | disclosed |
| CN-114650868-A | Small molecule degradation agent of HELIOS and use method thereof | 达纳-法伯癌症研究公司 | 2022-06-21 | — | — | CN | disclosed |