Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.62 |
| ▸ | INSR | P06213 | 5/20 | 0.60 |
| ▸ | TTK | P33981 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | ERN1 | O75460 | 2/20 | 0.60 |
| ▸ | STK10 | O94804 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | YES1 | P07947 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051190 | 1.00 | FES (0.72) | FESFLT3ALKINSRTTK | |
| SCHEMBL3958582 | 0.91 | FES (0.87) | FESFLT3ALKINSRTTK | |
| SCHEMBL12892763 | 0.88 | ALK (0.77) | FESFLT3ALKINSRTTK | |
| SCHEMBL3953410 | 0.87 | FES (0.82) | FESFLT3ALKINSRTTK | |
| SCHEMBL12781758 | 0.87 | ALK (0.78) | FESFLT3ALKINSRTTK | |
| SCHEMBL4059104 | 0.85 | ALK (0.64) | FESFLT3ALKINSRTTK | |
| SCHEMBL3954048 | 0.84 | FES (1.00) | FESFLT3ALKINSRTTK | |
| SCHEMBL4045834 | 0.82 | FES (0.84) | FESFLT3ALKINSRTTK | |
| SCHEMBL3950992 | 0.82 | ZAP70 (0.63) | FESFLT3ALKINSRTTK | |
| SCHEMBL14866516 | 0.82 | ALK (0.86) | FESFLT3ALKINSRTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110234773-B | Methods of treating cancer comprising fusion genes | 匹兹堡大学联邦系统高等教育 | 2024-07-02 | — | — | CN | disclosed |
| US-20220290257-A1 | METHODS OF TREATING CANCERS CONTAINING FUSION GENES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-09-15 | — | — | US | disclosed |
| US-11384400-B2 | Methods of treating cancers containing fusion genes | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-07-12 | — | — | US | disclosed |