Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24127737 | 1.00 | PDE10A (0.35) | PDE10AHIF1ACHRM4ADORA2AADORA1 | |
| SCHEMBL29720410 | 0.94 | HIF1A (0.33) | PDE10AHIF1ANPSR1ALDH1A1KDM4E | |
| SCHEMBL24127729 | 0.94 | HIF1A (0.33) | PDE10AHIF1ANPSR1ALDH1A1KDM4E | |
| SCHEMBL26038290 | 0.90 | HIF1A (0.37) | HIF1ANPSR1ALDH1A1KDM4EHPGD | |
| SCHEMBL26038980 | 0.89 | HIF1A (0.33) | HIF1ANPSR1SMN1; SMN2 | |
| SCHEMBL30481879 | 0.88 | SYK (0.35) | PDE10ACHRM4ALDH1A1KDM4EHPGD | |
| SCHEMBL24128101 | 0.88 | SYK (0.35) | PDE10ACHRM4ALDH1A1KDM4EHPGD | |
| SCHEMBL26038293 | 0.87 | POLB (0.38) | PDE10AHIF1AALDH1A1KDM4EHPGD | |
| SCHEMBL24128070 | 0.86 | KDM4E (0.34) | ADORA2AADORA1NPSR1ALDH1A1KDM4E | |
| SCHEMBL29720528 | 0.86 | KDM4E (0.34) | ADORA2AADORA1NPSR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168414-A1 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | Shy Therapeutics LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2021257828-A9 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2022-07-21 | — | — | WO | disclosed |