Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | KRAS | P01116 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24128147 | 1.00 | PRKCI (0.42) | PRKCIKRASCYP19A1PDE10ARAB9A | |
| SCHEMBL20665754 | 0.83 | KDM4E (0.49) | CYP19A1PDE10ARAB9AKDM4EALDH1A1 | |
| SCHEMBL29720453 | 0.81 | PRKCI (0.44) | PRKCIKRASCYP19A1PDE10ARAB9A | |
| SCHEMBL24128044 | 0.81 | PRKCI (0.44) | PRKCIKRASCYP19A1PDE10ARAB9A | |
| SCHEMBL20665617 | 0.79 | PDE10A (0.41) | KRASCYP19A1PDE10ARAB9AKDM4E | |
| SCHEMBL20665556 | 0.78 | KDM4E (0.36) | PRKCIKRASCYP19A1PDE10ARAB9A | |
| SCHEMBL26038698 | 0.76 | PDE10A (0.44) | KRASCYP19A1PDE10ARAB9AKDM4E | |
| SCHEMBL24827580 | 0.75 | PDE10A (0.45) | KRASCYP19A1PDE10ARAB9AKDM4E | |
| SCHEMBL24128157 | 0.75 | KDM4E (0.41) | PRKCICYP19A1PDE10ARAB9AKDM4E | |
| SCHEMBL29720643 | 0.75 | KDM4E (0.41) | PRKCICYP19A1PDE10ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168414-A1 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | Shy Therapeutics LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2021257828-A9 | SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2022-07-21 | — | — | WO | disclosed |