Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 12/20 | 0.69 |
| ▸ | FYN | P06241 | 6/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27180545 | 1.00 | HCRTR2 (0.69) | HCRTR2FYNPIK3CAPIK3CGBMPR1A | |
| SCHEMBL27180539 | 1.00 | HCRTR2 (0.69) | HCRTR2FYNPIK3CAPIK3CGBMPR1A | |
| SCHEMBL27180541 | 1.00 | HCRTR2 (0.69) | HCRTR2FYNPIK3CAPIK3CGBMPR1A | |
| SCHEMBL29723797 | 1.00 | HCRTR2 (0.69) | HCRTR2FYNPIK3CAPIK3CGBMPR1A | |
| SCHEMBL24529480 | 0.83 | HCRTR2 (0.75) | HCRTR2 | |
| SCHEMBL27179451 | 0.83 | HCRTR2 (0.75) | HCRTR2 | |
| SCHEMBL27179453 | 0.83 | HCRTR2 (0.75) | HCRTR2 | |
| SCHEMBL27179481 | 0.82 | HCRTR2 (1.00) | HCRTR2FYN | |
| SCHEMBL24529303 | 0.82 | HCRTR2 (1.00) | HCRTR2FYN | |
| SCHEMBL27179483 | 0.82 | HCRTR2 (1.00) | HCRTR2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262788-A1 | UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |