Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.64 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.64 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.64 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.64 |
| ▸ | AGPS | O00116 | 2/20 | 0.64 |
| ▸ | MYO1F | O00160 | 2/20 | 0.64 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.64 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.64 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.64 |
| ▸ | PGRMC1 | O00264 | 2/20 | 0.64 |
| ▸ | CLIC1 | O00299 | 2/20 | 0.64 |
| ▸ | CDC7 | O00311 | 2/20 | 0.64 |
| ▸ | IPO5 | O00410 | 2/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | COXFA4 | O00483 | 2/20 | 0.64 |
| ▸ | NOP56 | O00567 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29728052 | 0.89 | BRAF (0.81) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL24532038 | 0.89 | BRAF (0.81) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL29728047 | 0.87 | ABL1 (0.63) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL29931136 | 0.78 | ABL1 (1.00) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL16111548 | 0.78 | ABL1 (1.00) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL4699140 | 0.78 | BRAF (0.80) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL24532075 | 0.77 | BRAF (0.89) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL4696222 | 0.75 | BRAF (0.72) | ABL1EGFRPDGFRBESYT2NBAS | |
| SCHEMBL15529261 | 0.71 | RXFP1 (1.00) | BRAFRXFP1CSF1RMEN1TSHR | |
| SCHEMBL15528884 | 0.70 | RXFP1 (1.00) | RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486270-B2 | Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2025-12-02 | — | — | US | disclosed |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486270-B2 | Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder | EPHA1, EPHB2, EPHB1 | ABL1 75/4885EGFR 27/4885PDGFRB 658/4885 |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | EPHA1, EPHB2, EPHB1 | ABL1 75/4885EGFR 27/4885PDGFRB 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.