Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.98 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.82 |
| ▸ | CIT | O14578 | 1/20 | 0.82 |
| ▸ | GAK | O14976 | 1/20 | 0.82 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.82 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.82 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.82 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.82 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.82 |
| ▸ | STK17B | O94768 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.82 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.82 |
| ▸ | ABL1 | P00519 | 1/20 | 0.82 |
| ▸ | LCK | P06239 | 1/20 | 0.82 |
| ▸ | LYN | P07948 | 1/20 | 0.82 |
| ▸ | RET | P07949 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222431 | 1.00 | EGFR (0.98) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL22962690 | 0.92 | EGFR (0.84) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL12012 | 0.92 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL17520338 | 0.92 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL22338480 | 0.92 | EGFR (0.92) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL11395 | 0.92 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL22336591 | 0.90 | EGFR (0.86) | EGFRERBB2CITGAKEPHB6 | |
| Gefitinib SCHEMBL29351046 | 0.90 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 | |
| Gefitinib SCHEMBL29351336 | 0.90 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 | |
| Gefitinib SCHEMBL465143 | 0.90 | EGFR (1.00) | EGFRERBB2CITGAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119823212-A | Tumor targeting self-assembled nano preparation based on protein degradation technology and preparation method and application thereof | 铜仁职业技术学院 | 2025-04-15 | — | — | CN | claimed |
| EP-4612149-A1 | PYRIDO[2,3-D]PYRIMIDIN-2-AMINE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| CN-119823212-A | Tumor targeting self-assembled nano preparation based on protein degradation technology and preparation method and application thereof | 铜仁职业技术学院 | 2025-04-15 | — | — | CN | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |
| CN-112321566-B | EGFR protein degradation agent and anti-tumor application thereof | 上海科技大学 | 2022-06-10 | — | — | CN | disclosed |