SCHEMBL29731535

SCHEMBL29731535

O=C1c2ccc(Cl)cc2CCCN1C[C@H](O)CN1CCc2ccccc2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 1.00
WDR77 Q9BQA1 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23160280 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL23160282 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL23160673 0.91 PRMT5 (1.00) PRMT5WDR77
SCHEMBL29731301 0.91 PRMT5 (1.00) PRMT5WDR77
SCHEMBL23190429 0.91 PRMT5 (1.00) PRMT5WDR77
SCHEMBL29731190 0.88 PRMT5 (0.80) PRMT5WDR77
SCHEMBL23160131 0.88 PRMT5 (0.80) PRMT5WDR77
SCHEMBL28823704 0.88 PRMT5 (0.80) PRMT5WDR77
SCHEMBL23160168 0.88 PRMT5 (1.00) PRMT5WDR77
SCHEMBL23160171 0.88 PRMT5 (1.00) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024101965-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE 에스케이바이오팜 주식회사 2024-05-16 WO claimed
CN-114929691-A Bicyclic compounds and uses thereof 爱思开生物制药株式会社 2022-08-19 CN claimed
EP-4039686-A1 BICYCLIC COMPOUND AND USE THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2022-08-10 EP claimed
WO-2024101965-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE 에스케이바이오팜 주식회사 2024-05-16 WO disclosed
EP-4039686-A1 BICYCLIC COMPOUND AND USE THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2022-08-10 EP disclosed