Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.79 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.79 |
| ▸ | JAK3 | P52333 | 2/20 | 0.79 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.77 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | SRC | P12931 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.76 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | MC3R | P41968 | 1/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869099 | 1.00 | EGFR (0.79) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL869098 | 1.00 | EGFR (0.79) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL17498544 | 0.94 | EGFR (0.71) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL16398699 | 0.93 | EGFR (0.79) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL16398696 | 0.93 | EGFR (0.79) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL25829 | 0.92 | EGFR (0.80) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL18862642 | 0.92 | EGFR (0.80) | EGFRERBB2ERBB4JAK3ERBB3 | |
| SCHEMBL16405547 | 0.92 | EGFR (0.83) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL17498519 | 0.92 | EGFR (0.83) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL18427450 | 0.92 | EGFR (0.79) | EGFRERBB2ERBB4JAK3ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304170-A | Bifunctional molecule capable of degrading EGFR mutant and preparation method and application thereof | 中国药科大学 | 2023-12-29 | — | — | CN | disclosed |
| CN-112321566-B | EGFR protein degradation agent and anti-tumor application thereof | 上海科技大学 | 2022-06-10 | — | — | CN | disclosed |