Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 12/20 | 0.87 |
| ▸ | EGFR | P00533 | 10/20 | 0.87 |
| ▸ | GAK | O14976 | 1/20 | 0.86 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.86 |
| ▸ | LYN | P07948 | 1/20 | 0.86 |
| ▸ | RET | P07949 | 1/20 | 0.86 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.86 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.86 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.86 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.86 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.86 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.86 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.86 |
| ▸ | ADK | P55263 | 1/20 | 0.86 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.86 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884254 | 1.00 | ERBB2 (0.87) | ERBB2EGFRGAKRIPK2LYN | |
| Hydrochloric Acid SCHEMBL4878789 | 0.99 | ERBB2 (0.86) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3129641 | 0.93 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL202358 | 0.92 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL29728247 | 0.92 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL30362790 | 0.92 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL4885136 | 0.92 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL4883773 | 0.91 | ERBB2 (1.00) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL5422908 | 0.91 | EGFR (0.85) | ERBB2EGFRGAKRIPK2LYN | |
| Sapitinib SCHEMBL201895 | 0.90 | ERBB2 (0.92) | ERBB2EGFRGAKRIPK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321566-B | EGFR protein degradation agent and anti-tumor application thereof | 上海科技大学 | 2022-06-10 | — | — | CN | disclosed |