Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 18/20 | 0.67 |
| ▸ | AURKA | O14965 | 10/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | PLK1 | P53350 | 3/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897199 | 0.84 | TTK (0.73) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1558514 | 0.84 | TTK (0.73) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1560094 | 0.79 | TTK (0.65) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL12698362 | 0.79 | TTK (0.65) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL31326950 | 0.78 | CCNA2 (0.57) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL10220785 | 0.78 | CCNA2 (0.57) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1559118 | 0.78 | TTK (0.79) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1560122 | 0.78 | TTK (0.79) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1558678 | 0.78 | TTK (0.79) | TTKAURKACCNA2CDK2PLK1 | |
| SCHEMBL1560051 | 0.77 | TTK (0.70) | TTKAURKACCNA2CDK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110896636-B | Salts of compounds that inhibit MPS1 kinase, preparation thereof and formulations comprising the same | 内尔维亚诺医疗科学公司 | 2022-07-19 | — | — | CN | disclosed |