Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.86 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23087567 | 1.00 | PRMT5 (0.86) | PRMT5WDR77 | |
| SCHEMBL23099142 | 0.94 | PRMT5 (0.80) | PRMT5WDR77 | |
| SCHEMBL29735158 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL23087820 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL23087913 | 0.91 | PRMT5 (0.88) | PRMT5WDR77 | |
| SCHEMBL29735157 | 0.91 | PRMT5 (0.88) | PRMT5WDR77 | |
| SCHEMBL23088786 | 0.91 | PRMT5 (0.70) | PRMT5WDR77 | |
| SCHEMBL23099141 | 0.89 | PRMT5 (0.88) | PRMT5WDR77 | |
| SCHEMBL23087634 | 0.88 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL29735174 | 0.88 | PRMT5 (1.00) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | disclosed |
| EP-4028388-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |