Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2413394 | 1.00 | CSF1R (0.48) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL2030714 | 0.87 | CSF1R (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736796 | 0.87 | CSF1R (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736560 | 0.86 | CSF1R (0.55) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736609 | 0.86 | CSF1R (0.50) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL23071266 | 0.86 | CSF1R (0.50) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL2418677 | 0.86 | CSF1R (0.55) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL2414132 | 0.84 | KDR (0.48) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL574068 | 0.83 | KDR (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736768 | 0.83 | KDR (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283916-B | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-116283916-A | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-112457295-B | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2022-07-26 | — | — | CN | disclosed |
| EP-4029862-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-07-20 | — | — | EP | disclosed |