Leucine

Leucine

SCHEMBL2973802

CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.N[C@@H](CS)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.58
PTGS1 P23219 1/20 0.52
SLC7A11 Q9UPY5 1/20 0.52
SLC1A2 P43004 7/20 0.47
SLC1A3 P43003 6/20 0.47
SLC1A1 P43005 6/20 0.44
ENPEP Q07075 3/20 0.40
GRIK1 P39086 5/20 0.39
GRIK2 Q13002 4/20 0.39
RNPEP Q9H4A4 1/20 0.36
DPP4 P27487 1/20 0.35
DPP8 Q6V1X1 1/20 0.35
DPP9 Q86TI2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL2973800 1.00 SLC7A5 (0.58) SLC7A5PTGS1SLC7A11SLC1A2SLC1A3
Leucine SCHEMBL3497004 0.94 SLC7A5 (0.51) SLC7A5PTGS1SLC7A11SLC1A2SLC1A3
Leucine SCHEMBL122271 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Isoleucine SCHEMBL6809072 0.92 PTGS1 (0.61) SLC7A5PTGS1SLC7A11SLC1A2SLC1A3
D-Leucine SCHEMBL1537398 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL1537204 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Isoleucine SCHEMBL10610189 0.92 PTGS1 (0.61) SLC7A5PTGS1SLC7A11SLC1A2SLC1A3
Leucine SCHEMBL3314487 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL122270 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL18249997 0.92 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080190894-A1 Chemical Mechanical Polishing Slurries, Their Applications and Method of Use Thereof ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) 2008-08-14 US claimed
US-7776231-B2 Chemical mechanical polishing slurries, their applications and method of use thereof ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) 2010-08-17 US disclosed
US-20080190894-A1 Chemical Mechanical Polishing Slurries, Their Applications and Method of Use Thereof ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) 2008-08-14 US disclosed
EP-0492560-B1 Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of HIV-1, and related peptides BIOCLONETICS INC (US) 2001-10-10 EP disclosed
EP-1016671-A2 Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) Cotropia, Joseph P. (US) 2000-07-05 EP disclosed
EP-0492560-A2 Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of HIV-1, and related peptides Cotropia, Joseph P. (US) 1992-07-01 EP disclosed