Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.52 |
| ▸ | USP7 | Q93009 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | TEC | P42680 | 2/20 | 0.44 |
| ▸ | BMX | P51813 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741216 | 0.76 | AR (0.50) | ARBTKLCKFGFR1USP7 | |
| SCHEMBL15288101 | 0.76 | BTK (0.60) | ARBTKLCKFGFR1USP7 | |
| SCHEMBL29740965 | 0.75 | BTK (0.59) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL3378316 | 0.75 | BTK (0.59) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL29740440 | 0.73 | AR (0.54) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL15288538 | 0.72 | BTK (1.00) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL15288618 | 0.71 | BTK (0.54) | ARBTKLCKFGFR1USP7 | |
| SCHEMBL27690287 | 0.71 | FGFR1 (0.54) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL29741225 | 0.71 | BTK (0.54) | ARBTKLCKFGFR1FGFR2 | |
| SCHEMBL15296451 | 0.70 | BTK (0.70) | ARBTKLCKFGFR1USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |