Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 19/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 19/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29744811 | 1.00 | DDB1 (0.50) | DDB1CRBNMEN1MAPTKMT2A | |
| SCHEMBL23538467 | 1.00 | DDB1 (0.50) | DDB1CRBNMEN1MAPTKMT2A | |
| SCHEMBL23538593 | 1.00 | DDB1 (0.50) | DDB1CRBNMEN1MAPTKMT2A | |
| SCHEMBL31334059 | 0.93 | DDB1 (0.45) | DDB1CRBNMEN1MAPTKMT2A | |
| SCHEMBL29535329 | 0.87 | CRBN (0.47) | DDB1CRBN | |
| SCHEMBL23538676 | 0.87 | CRBN (0.47) | DDB1CRBN | |
| SCHEMBL23538440 | 0.87 | CRBN (0.47) | DDB1CRBN | |
| SCHEMBL29946960 | 0.87 | CRBN (0.47) | DDB1CRBN | |
| SCHEMBL23538280 | 0.87 | CRBN (0.47) | DDB1CRBN | |
| SCHEMBL29744780 | 0.87 | CRBN (0.47) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901277-B | Isoindolinone and indazole compounds for EGFR degradation | C4医药公司 | 2024-05-17 | — | — | CN | disclosed |
| EP-4076450-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-114901277-A | Isoindolinone and indazole compounds for EGFR degradation | C4医药公司 | 2022-08-12 | — | — | CN | disclosed |