Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.72 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 5/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641841 | 1.00 | ESR1 (0.72) | ESR1ESR2NR1H2PKMABHD6 | |
| Hydrochloric Acid SCHEMBL1639774 | 0.99 | ESR1 (0.70) | ESR1ESR2NR1H2PKMABHD6 | |
| SCHEMBL4179872 | 0.94 | ESR2 (0.72) | ESR1ESR2NR1H2PKMABHD6 | |
| SCHEMBL3353692 | 0.92 | ESR1 (0.60) | ESR1ESR2NR1H2PKMABHD6 | |
| SCHEMBL373718 | 0.91 | ESR1 (0.58) | ESR1ESR2NR1H2PKMABHD6 | |
| SCHEMBL29986831 | 0.88 | ESR1 (0.54) | ESR1ESR2NR1H2ABHD6HDAC6 | |
| SCHEMBL5913288 | 0.88 | ESR1 (0.54) | ESR1ESR2NR1H2ABHD6HDAC6 | |
| SCHEMBL4183920 | 0.84 | ESR1 (0.74) | ESR1ESR2PKMABHD6MERTK | |
| SCHEMBL28947577 | 0.83 | ESR1 (0.52) | ESR1ESR2NR1H2PKMABHD6 | |
| SCHEMBL8266789 | 0.82 | ESR1 (0.72) | ESR1ESR2NR1H2PKMABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433059-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | Erasca, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| CN-114867718-A | Novel indazole derivative and use thereof | 韩国化学研究院 | 2022-08-05 | — | — | CN | disclosed |
| CN-114829344-A | Novel pyrimidine derivative and use thereof | 韩国化学研究院 | 2022-07-29 | — | — | CN | disclosed |