Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 15/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 15/20 | 0.51 |
| ▸ | EIF4E | P06730 | 10/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16621331 | 1.00 | MKNK1 (0.51) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL17969595 | 0.91 | MKNK1 (0.51) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL24520094 | 0.90 | MKNK1 (0.50) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL16625848 | 0.90 | MKNK1 (0.55) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL16621447 | 0.88 | MKNK1 (0.49) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL19841344 | 0.88 | MKNK1 (0.48) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL16620611 | 0.88 | MKNK1 (0.53) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL17998760 | 0.86 | MKNK1 (0.51) | MKNK1MKNK2EIF4EKCNH2CYP3A4 | |
| SCHEMBL18012832 | 0.86 | MKNK1 (0.51) | MKNK1MKNK2PLK4JAK2MAP4K4 | |
| SCHEMBL16620931 | 0.86 | MKNK1 (0.49) | MKNK1MKNK2EIF4EPLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |