Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 16/20 | 0.64 |
| ▸ | MKNK2 | Q9HBH9 | 16/20 | 0.64 |
| ▸ | EIF4E | P06730 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16621118 | 1.00 | MKNK1 (0.64) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL16620305 | 0.90 | MKNK1 (0.63) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL29756278 | 0.90 | MKNK1 (0.63) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL16626002 | 0.88 | MKNK1 (0.61) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL16620849 | 0.88 | MKNK1 (0.79) | MKNK1MKNK2EIF4ECYP3A4KCNH2 | |
| SCHEMBL16620738 | 0.88 | MKNK1 (0.60) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL29756323 | 0.88 | MKNK1 (0.60) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL16621478 | 0.87 | MKNK1 (0.64) | MKNK1MKNK2EIF4ECYP3A4KCNH2 | |
| SCHEMBL16621031 | 0.87 | MKNK1 (0.59) | MKNK1MKNK2EIF4ECYP3A4MTOR | |
| SCHEMBL16621224 | 0.85 | MKNK1 (0.61) | MKNK1MKNK2EIF4ECYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |