Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 6/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2530102 | 0.76 | PRKCI (0.38) | DYRK1AHDAC6FYN | |
| SCHEMBL24577874 | 0.71 | FLT3 (0.38) | DYRK1AFLT3JAK2JAK1TYK2 | |
| SCHEMBL9827034 | 0.69 | FYN (0.57) | DYRK1AFLT3BRD4KITEPHX2 | |
| SCHEMBL15729473 | 0.68 | CYP2A6 (0.51) | FLT3PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24853024 | 0.67 | — | — | |
| SCHEMBL20004395 | 0.67 | PIK3CG (0.44) | DYRK1AFLT3BRD4PIK3CDPIK3CA | |
| SCHEMBL22792789 | 0.67 | RET (0.45) | DYRK1AFLT3PIK3CGNEK2ADRA2A | |
| SCHEMBL2035062 | 0.67 | CHEK1 (0.50) | DYRK1ABRD4EPHX2AXLFYN | |
| SCHEMBL24577338 | 0.66 | HDAC6 (0.39) | FLT3BRD4HDAC6PIK3CGKIT | |
| SCHEMBL24576968 | 0.66 | BRD4 (0.41) | FLT3BRD4HDAC6PIK3CGNEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |