Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 5/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759955 | 1.00 | USP30 (0.40) | USP30GLSIRAK1CSF1RKIT | |
| SCHEMBL24579038 | 1.00 | USP30 (0.40) | USP30GLSIRAK1CSF1RKIT | |
| SCHEMBL24579089 | 0.93 | KAT6A (0.36) | USP30GLSIRAK4CETPIDO1 | |
| SCHEMBL24577514 | 0.93 | KAT6A (0.36) | USP30GLSIRAK4CETPIDO1 | |
| SCHEMBL29759770 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A | |
| SCHEMBL29760106 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A | |
| SCHEMBL24577577 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A | |
| SCHEMBL24577720 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A | |
| SCHEMBL30566605 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A | |
| SCHEMBL27185042 | 0.86 | GSK3B (0.38) | USP30CSF1RKITGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |