Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579033 | 1.00 | KIT (0.33) | KITCSF1RARKDRGSK3B | |
| SCHEMBL27185325 | 0.91 | KIT (0.35) | KITCSF1RKDRCHRM1PDGFRA | |
| SCHEMBL24579034 | 0.90 | KIT (0.35) | KITCSF1RKDRCHRM1PDGFRA | |
| SCHEMBL24577084 | 0.88 | IKBKE (0.37) | KITCSF1RARGSK3BDYRK1A | |
| SCHEMBL24576975 | 0.88 | CSF1R (0.42) | KITCSF1RGSK3BDYRK1ACHRM1 | |
| SCHEMBL29759653 | 0.88 | CSF1R (0.42) | KITCSF1RGSK3BDYRK1ACHRM1 | |
| SCHEMBL24579164 | 0.86 | KIT (0.39) | KITKDRCHRM1PDGFRAHRH3 | |
| SCHEMBL24577335 | 0.85 | IKBKE (0.41) | KITCSF1RARGSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL29760043 | 0.85 | KIT (0.38) | KITKDRCHRM1PDGFRAHRH3 | |
| Hydrochloric Acid SCHEMBL27184986 | 0.85 | KIT (0.38) | KITKDRCHRM1PDGFRAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |