Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984264 | 0.91 | HPGD (0.52) | GRM4HPGDNPC1ALDH1A1RAB9A | |
| SCHEMBL30302489 | 0.83 | GRM4 (0.50) | GRM4CYP1A2CYP2D6CYP2C9CYP3A4 | |
| SCHEMBL22803760 | 0.83 | GRM4 (0.50) | GRM4CYP1A2CYP2D6CYP2C9CYP3A4 | |
| SCHEMBL30302532 | 0.78 | EGFR (0.58) | GRM4CYP1A2FGFR2FLT3EGFR | |
| SCHEMBL22803766 | 0.78 | EGFR (0.47) | GRM4CYP1A2FGFR2FLT3EGFR | |
| SCHEMBL30302566 | 0.78 | EGFR (0.47) | GRM4CYP1A2FGFR2FLT3EGFR | |
| SCHEMBL22803770 | 0.78 | EGFR (0.58) | GRM4CYP1A2FGFR2FLT3EGFR | |
| SCHEMBL22803772 | 0.77 | IGF1R (0.46) | GRM4CYP1A2FGFR2FLT3EGFR | |
| SCHEMBL8877814 | 0.76 | MAPT (0.54) | GRM4NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2975973 | 0.74 | PRKCQ (0.55) | PRKCQPRKCDLYNFGFR2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | GRM4 3273/4885HPGD 2483/4885NPC1 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.