Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20517501 | 0.83 | MAPT (0.38) | ALDH1A1HPGDTSHRMAPTHSD17B10 | |
| SCHEMBL24547863 | 0.83 | GAA (0.40) | ALDH1A1HPGDTSHRMAPTLMNA | |
| SCHEMBL16100242 | 0.78 | ELANE (0.38) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL16100621 | 0.78 | GAA (0.40) | ALDH1A1HPGDTSHRMAPTLMNA | |
| SCHEMBL30133793 | 0.78 | GAA (0.42) | ALDH1A1HPGDTSHRMAPTLMNA | |
| SCHEMBL16100622 | 0.78 | GAA (0.40) | ALDH1A1HPGDTSHRMAPTLMNA | |
| SCHEMBL16100241 | 0.78 | ELANE (0.38) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL31622731 | 0.78 | ELANE (0.38) | ALDH1A1HPGDTSHRMAPTKDM4E | |
| SCHEMBL30758185 | 0.78 | GAA (0.40) | ALDH1A1HPGDTSHRMAPTKDM4E | |
| SCHEMBL30133959 | 0.76 | ELANE (0.38) | ALDH1A1HPGDTSHRKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288435-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | Amgen Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-117062816-A | Tricyclic-amide-bicyclic PRMT5 inhibitors | 美国安进公司 | 2023-11-14 | — | — | CN | disclosed |
| EP-4263545-A1 | PRMTS INHIBITORS | Amgen Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116888120-A | PRMTS inhibitors | 美国安进公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022169948-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |