SCHEMBL29761986

SCHEMBL29761986

c1ccc(Cn2nnnc2C(c2cccnc2)N2CCN(C(c3cccnc3)c3nnnn3Cc3ccccc3)CC2)cc1

nearest known ligand 0.89

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC1A2 P43004 6/20 0.89
SLC1A3 P43003 5/20 0.89
NPSR1 Q6W5P4 5/20 0.87
MAPK1 P28482 4/20 0.87
SLC1A1 P43005 1/20 0.85
ALDH1A1 P00352 7/20 0.79
GAA P10253 3/20 0.79
ALOX15 P16050 2/20 0.79
HSD17B10 Q99714 2/20 0.79
HRH3 Q9Y5N1 3/20 0.72
HRH4 Q9H3N8 1/20 0.72
KMT2A Q03164 1/20 0.70
POLB P06746 1/20 0.67
USP2 O75604 2/20 0.62
RECQL P46063 1/20 0.62
LMNA P02545 2/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
TSHR P16473 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29761980 0.94 SLC1A2 (1.00) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL29761949 0.92 SLC1A2 (1.00) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL29761972 0.89 SLC1A2 (1.00) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL4023197 0.87 SLC1A2 (0.89) SLC1A2SLC1A3ALDH1A1GAAHRH3
SCHEMBL29761989 0.85 SLC1A2 (0.69) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL29761979 0.84 SLC1A2 (1.00) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL22899070 0.79 SLC1A2 (1.00) SLC1A2SLC1A3NPSR1MAPK1ALDH1A1
SCHEMBL29761978 0.78 HRH3 (0.74) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL29761958 0.78 HRH3 (0.74) SLC1A2SLC1A3NPSR1MAPK1SLC1A1
SCHEMBL29761967 0.78 SLC1A2 (0.83) SLC1A2SLC1A3NPSR1MAPK1SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220267308-A1 Modulators of Excitatory Amino Acid Transporters and Methods Using Same DREXEL UNIVERSITY 2022-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220267308-A1 Modulators of Excitatory Amino Acid Transporters and Methods Using Same SLC1A2, SLC1A1, SLC1A3 SLC1A2 1/4885SLC1A3 3/4885NPSR1 499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.