Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 1.00 |
| ▸ | DRD3 | P35462 | 11/20 | 1.00 |
| ▸ | DRD2 | P14416 | 9/20 | 0.75 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201893 | 1.00 | KCNH2 (1.00) | KCNH2DRD3DRD2MMP2MMP9 | |
| SCHEMBL13219171 | 1.00 | KCNH2 (1.00) | KCNH2DRD3DRD2MMP2MMP9 | |
| SCHEMBL13201900 | 0.86 | DRD3 (1.00) | KCNH2DRD3DRD2MAPT | |
| SCHEMBL13219174 | 0.86 | DRD3 (1.00) | KCNH2DRD3DRD2MAPT | |
| SCHEMBL13219278 | 0.85 | KCNH2 (1.00) | KCNH2DRD3DRD2SLC6A2SLC6A4 | |
| SCHEMBL13201899 | 0.85 | KCNH2 (1.00) | KCNH2DRD3DRD2SLC6A2SLC6A4 | |
| SCHEMBL13201895 | 0.85 | KCNH2 (0.73) | KCNH2DRD3DRD2SLC6A2SLC6A4 | |
| SCHEMBL13219296 | 0.85 | KCNH2 (0.73) | KCNH2DRD3DRD2SLC6A2SLC6A4 | |
| SCHEMBL2819451 | 0.83 | KCNH2 (0.68) | KCNH2DRD3DRD2SLC6A2SLC6A4 | |
| SCHEMBL378080 | 0.83 | KCNH2 (0.68) | KCNH2DRD3DRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776904-B2 | Azabicyclo [3.1.0] hexylphenyl derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2010-08-17 | — | — | US | claimed |