Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.73 |
| ▸ | LCK | P06239 | 7/20 | 0.73 |
| ▸ | SRC | P12931 | 4/20 | 0.73 |
| ▸ | TEK | Q02763 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.73 |
| ▸ | EGFR | P00533 | 7/20 | 0.67 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.65 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 4/20 | 0.64 |
| ▸ | ITK | Q08881 | 5/20 | 0.61 |
| ▸ | TEC | P42680 | 4/20 | 0.61 |
| ▸ | BMX | P51813 | 4/20 | 0.61 |
| ▸ | TXK | P42681 | 2/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.61 |
| ▸ | YES1 | P07947 | 2/20 | 0.61 |
| ▸ | HCK | P08631 | 2/20 | 0.61 |
| ▸ | FGR | P09769 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801409 | 1.00 | BTK (0.73) | BTKLCKSRCTEKKDR | |
| SCHEMBL6434918 | 1.00 | BTK (0.73) | BTKLCKSRCTEKKDR | |
| SCHEMBL6433918 | 1.00 | BTK (0.73) | BTKLCKSRCTEKKDR | |
| SCHEMBL30301968 | 0.95 | BTK (0.71) | BTKLCKSRCTEKKDR | |
| SCHEMBL26103890 | 0.95 | BTK (0.71) | BTKLCKSRCTEKKDR | |
| SCHEMBL5801559 | 0.95 | BTK (0.69) | BTKLCKSRCTEKKDR | |
| SCHEMBL22720698 | 0.95 | BTK (0.69) | BTKLCKSRCTEKKDR | |
| SCHEMBL22720690 | 0.95 | BTK (0.69) | BTKLCKSRCTEKKDR | |
| SCHEMBL22720717 | 0.95 | BTK (0.69) | BTKLCKSRCTEKKDR | |
| SCHEMBL29470248 | 0.95 | BTK (0.69) | BTKLCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114746095-B | HCK as therapeutic target of MYD88 mutant diseases | 达纳-法伯癌症研究所有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-118201929-A | PROTAC compound, pharmaceutical composition containing same, and preparation method and application thereof | 广东弘烨医药科技有限公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023072270-A1 | PROTAC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 百极弘烨(南通)医药科技有限公司 | 2023-05-04 | — | — | WO | disclosed |
| CN-114746095-A | HCK as therapeutic target of MYD88 mutant disease | 达纳-法伯癌症研究所有限公司 | 2022-07-12 | — | — | CN | disclosed |