Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 8/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30581371 | 0.92 | GRM1 (0.46) | GRM1GRM4PTK6LCKAURKB | |
| SCHEMBL30098796 | 0.90 | GRM1 (0.47) | GRM1GRM4PTK6LCKAURKB | |
| SCHEMBL30581385 | 0.88 | GRM1 (0.46) | GRM1GRM4PTK6LCKAURKB | |
| SCHEMBL30581370 | 0.83 | GRM1 (0.44) | GRM1GRM4PTK6LCKAURKB | |
| SCHEMBL29437653 | 0.83 | GRM1 (0.42) | GRM1GRM4PTK6NAMPTCBLB | |
| SCHEMBL30581367 | 0.83 | GRM1 (0.48) | GRM1GRM4PTK6NAMPT | |
| SCHEMBL30581373 | 0.82 | GRM4 (0.46) | GRM1GRM4PTK6ROCK1JAK3 | |
| SCHEMBL22405623 | 0.82 | LCK (0.47) | PTK6LCKAURKBCDK8ROCK1 | |
| SCHEMBL29402806 | 0.82 | LCK (0.47) | PTK6LCKAURKBCDK8ROCK1 | |
| Hydrochloric Acid SCHEMBL22405648 | 0.81 | LCK (0.46) | PTK6LCKAURKBCDK8ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288424-A1 | NOVEL HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167631-A1 | NOVEL HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-11 | — | — | WO | disclosed |