Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 11/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31438076 | 0.90 | CYP1A2 (0.55) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL16859487 | 0.90 | CYP1A2 (0.55) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL10794645 | 0.88 | CYP1A2 (0.54) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL13684801 | 0.85 | CYP1A2 (0.60) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL19574893 | 0.85 | CYP1A2 (0.60) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL8163254 | 0.82 | HSD17B10 (0.61) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL18215410 | 0.82 | HSD17B10 (0.61) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL28870083 | 0.79 | HSD17B10 (0.67) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL5658128 | 0.79 | HSD17B10 (0.58) | CYP1A2HSD17B10DRD4DRD3DRD2 | |
| SCHEMBL23777858 | 0.78 | HSD17B10 (0.60) | CYP1A2HSD17B10DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377483-B9 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-08-03 | — | — | EP | claimed |