Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20299409 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9KMT2ABTKJAK2 | |
| SCHEMBL29771165 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9KMT2ABTKJAK2 | |
| SCHEMBL20330486 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9KMT2ABTKJAK2 | |
| SCHEMBL20299315 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9KMT2ABTKJAK2 | |
| SCHEMBL29501906 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9KMT2ABTKJAK2 | |
| SCHEMBL29501867 | 0.93 | MAPK8 (0.43) | MAPK8MAPK9KMT2ABTKMAPK1 | |
| SCHEMBL21593678 | 0.93 | MAPK8 (0.43) | MAPK8MAPK9KMT2ABTKMAPK1 | |
| SCHEMBL21591892 | 0.93 | MAPK8 (0.43) | MAPK8MAPK9KMT2ABTKMAPK1 | |
| SCHEMBL20299476 | 0.93 | MAPK8 (0.43) | MAPK8MAPK9KMT2ABTKMAPK1 | |
| Fluoride SCHEMBL13518132 | 0.87 | KMT2A (0.57) | MAPK8KMT2AJAK2SYKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112236431-B | Purinone Compounds and Their Use in the Treatment of Cancer | 阿斯利康(瑞典)有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-110177791-B | Amino-triazolopyridine compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2022-07-12 | — | — | CN | disclosed |