Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.49 |
| ▸ | TUBB | P07437 | 2/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250345 | 1.00 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29443894 | 1.00 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL223844 | 1.00 | MDM2 (0.53) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29875754 | 0.90 | LRRK2 (0.60) | MDM2LRRK2PDGFRBCDK2TGM2 | |
| SCHEMBL28711339 | 0.90 | LRRK2 (0.60) | MDM2LRRK2PDGFRBCDK2TGM2 | |
| SCHEMBL14659628 | 0.90 | NPC1 (0.56) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14659629 | 0.90 | NPC1 (0.56) | MDM2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2739255 | 0.88 | NPC1 (0.47) | MDM2NPC1PDGFRBTGM2MEN1 | |
| SCHEMBL14658998 | 0.88 | MEN1 (0.52) | MDM2NPC1PDGFRBMEN1KMT2A | |
| SCHEMBL6822268 | 0.88 | NPC1 (0.47) | MDM2NPC1PDGFRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447959-A1 | METHODS OF TREATING CANCER | Kymera Therapeutics, Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118574613-A | Methods of treating cancer | 凯麦拉医疗公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023114933-A1 | METHODS OF TREATING CANCER | KYMERA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| CN-115776887-A | MDM2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2023-03-10 | — | — | CN | disclosed |
| EP-4121043-A1 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-113387957-B | Spirocyclic indolone-pyrrolidine carbonate compound and composition, preparation method and application thereof | 江苏亚尧生物科技有限公司 | 2022-08-09 | — | — | CN | disclosed |