Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 20/20 | 0.62 |
| ▸ | VEGFA | P15692 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461045 | 1.00 | EPAS1 (0.62) | EPAS1VEGFA | |
| SCHEMBL29780222 | 0.88 | EPAS1 (0.62) | EPAS1VEGFA | |
| SCHEMBL29780186 | 0.88 | EPAS1 (0.63) | EPAS1VEGFA | |
| SCHEMBL23461102 | 0.88 | EPAS1 (0.63) | EPAS1VEGFA | |
| SCHEMBL23461573 | 0.88 | EPAS1 (0.62) | EPAS1VEGFA | |
| SCHEMBL23478137 | 0.85 | EPAS1 (0.55) | EPAS1VEGFA | |
| SCHEMBL29780201 | 0.85 | EPAS1 (0.55) | EPAS1VEGFA | |
| SCHEMBL23478337 | 0.83 | EPAS1 (0.51) | EPAS1VEGFA | |
| SCHEMBL24910331 | 0.82 | EPAS1 (0.61) | EPAS1VEGFA | |
| SCHEMBL23461501 | 0.81 | EPAS1 (0.63) | EPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069212-A1 | INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |
| CN-114760994-A | Inhibitors of HIF-2 alpha | 艾库斯生物科学有限公司 | 2022-07-15 | — | — | CN | disclosed |