Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | JAK1 | P23458 | 6/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003253 | 0.84 | CA12 (0.48) | LRRK2JAK2JAK1MAP4K4ULK1 | |
| SCHEMBL2564647 | 0.82 | CA12 (0.44) | JAK2JAK1MAP4K4ULK1CA12 | |
| SCHEMBL30050848 | 0.82 | CA12 (0.44) | JAK2JAK1MAP4K4ULK1CA12 | |
| SCHEMBL29781603 | 0.80 | JAK2 (0.56) | NTRK1LRRK2JAK2JAK1ULK1 | |
| SCHEMBL4006767 | 0.80 | LRRK2 (0.53) | LRRK2JAK2JAK1AURKA | |
| SCHEMBL1141610 | 0.78 | JAK2 (0.51) | NTRK1JAK2MAP4K4CSNK2A1 | |
| SCHEMBL7369787 | 0.76 | CA12 (0.51) | NTRK1JAK2MAP4K4CA12CA1 | |
| SCHEMBL30432899 | 0.75 | CA12 (0.47) | NTRK1JAK2MAP4K4CA12CA1 | |
| SCHEMBL7368266 | 0.75 | CA12 (0.47) | NTRK1JAK2MAP4K4CA12CA1 | |
| SCHEMBL25777219 | 0.75 | CA12 (0.47) | NTRK1JAK2MAP4K4CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490751-A | Factor D inhibitors | 拜奥克里斯特制药公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-109121414-B | Benzopyrazole compounds and analogs thereof | 拜奥克里斯特制药公司 | 2022-07-05 | — | — | CN | disclosed |