⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203032 | 1.00 | — | — | |
| SCHEMBL2975896 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL7712938 | 0.97 | RNPEP (0.95) | — | |
| SCHEMBL11664443 | 0.83 | — | — | |
| SCHEMBL3093445 | 0.82 | RNPEP (0.68) | — | |
| SCHEMBL3821790 | 0.81 | — | — | |
| SCHEMBL8517982 | 0.77 | RNPEP (0.62) | — | |
| SCHEMBL11203612 | 0.77 | RNPEP (0.62) | — | |
| SCHEMBL4300073 | 0.76 | — | — | |
| SCHEMBL1405522 | 0.76 | RNPEP (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273008-B2 | Dual-acting imidazole antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-03-01 | — | — | US | disclosed |
| US-9198899-B2 | Dual-acting benzoimidazole antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-12-01 | — | — | US | disclosed |
| US-9150514-B2 | Dual-acting antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-10-06 | — | — | US | disclosed |
| US-20150191435-A1 | DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-07-09 | — | — | US | disclosed |
| US-9012485-B2 | Dual-acting imidazole antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-21 | — | — | US | disclosed |
| US-20150065543-A1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-03-05 | — | — | US | disclosed |
| US-20150011597-A1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC. (US) | 2015-01-08 | — | — | US | disclosed |
| EP-2146963-B1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R & D IP LLC (US) | 2014-12-17 | — | — | EP | disclosed |
| US-8895755-B2 | Intermediates for preparing dual-acting benzyl triazole antihypertensive agents having angiotensin II type I receptor antagonist activity and neprilysin-inhibition activity | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140303222-A1 | DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-10-09 | — | — | US | disclosed |
| US-20080269305-A1 | R)-N-{2-Butyl-3-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl}-2-(2-hydroxycarbamoyl-3-phenyl-propionylamino)succinamic Acid; AT1 receptor antagonist and neprilysin (NEP) enzyme inhibition activity; hypertension, heart failure | THERAVANCE, INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080188533-A1 | 2-Mercaptomethyl-4-methylpentanoic Acid (2-Butyryl-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]aminoethyl)amide | THERAVANCE BIOPHARMA R&D IP, LLC | 2008-08-07 | — | — | US | disclosed |
| US-5736517-A | ADMINISTERING TO TREAT COLON, PROSTATE OR BREAST CANCER | BIOMEASURE, INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0585397-B1 | BOMBESIN ANALOGS | MERRELL PHARMA INC (US) | 1997-08-06 | — | — | EP | disclosed |
| EP-0434979-B1 | Peptide derivatives useful as antagonists of bombesin and gastrin-releasing peptide | MERRELL DOW PHARMA (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5428019-A | Digestive system disorders; antitumor agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0585397-A1 | BOMBESIN ANALOGS. | MERRELL DOW PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| WO-1992020707-A1 | BOMBESIN ANALOGS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| US-5114925-A | Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxy-1-butyl]thio)alkanoyl moiety and the corresponding sulfoxide and sulfone derivatives | MERCK & CO., INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0434979-A1 | Peptide derivatives useful as antagonists of bombesin and gastrin-releasing peptide | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-07-03 | — | — | EP | disclosed |