Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | GLA | P06280 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28901024 | 0.87 | KDM4E (0.58) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL297573 | 0.84 | KDM4E (0.52) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL300925 | 0.82 | PIK3CD (0.70) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL19254654 | 0.82 | HDAC3 (0.70) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL298237 | 0.81 | KDM4E (0.75) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL27796448 | 0.81 | PIK3CD (0.71) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL300813 | 0.81 | KDM4E (0.74) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL15210094 | 0.80 | KDM4E (0.68) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL301153 | 0.80 | CSNK2A1 (0.73) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL291560 | 0.79 | KDM4E (0.81) | KDM4EGLAALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |