Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27229843 | 1.00 | HDAC6 (0.41) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL27229961 | 1.00 | HDAC6 (0.41) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL29784644 | 1.00 | HDAC6 (0.41) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL27229778 | 0.90 | PTPN2 (0.31) | HDAC6PTPN2 | |
| SCHEMBL29784719 | 0.90 | HDAC6 (0.31) | HDAC6 | |
| SCHEMBL27229820 | 0.85 | HDAC6 (0.39) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL27229744 | 0.85 | HDAC6 (0.39) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL29784683 | 0.85 | HDAC6 (0.39) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL29784636 | 0.85 | HDAC6 (0.39) | HDAC6HDAC4HDAC7HDAC11HDAC8 | |
| SCHEMBL26055712 | 0.82 | HDAC6 (0.32) | HDAC6HDAC4HDAC7HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169985-A1 | HDAC6 INHIBITORS AND USES THEREOF | EIKONIZO THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |