Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 1.00 |
| ▸ | DYRK2 | Q92630 | 3/20 | 1.00 |
| ▸ | RAF1 | P04049 | 2/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | AKT2 | P31751 | 2/20 | 1.00 |
| ▸ | KDR | P35968 | 2/20 | 1.00 |
| ▸ | PRKAG1 | P54619 | 2/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 2/20 | 1.00 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 1.00 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 1.00 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325644 | 1.00 | IKBKB (1.00) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL30593591 | 1.00 | IKBKB (1.00) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL1325643 | 1.00 | IKBKB (1.00) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL29363457 | 1.00 | IKBKB (1.00) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL8119310 | 1.00 | IKBKB (1.00) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| Hydrochloric Acid SCHEMBL29359400 | 0.98 | IKBKB (0.96) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| Acetic Acid SCHEMBL3187366 | 0.91 | IKBKB (0.82) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| Acetic Acid SCHEMBL3187370 | 0.91 | IKBKB (0.82) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL17300373 | 0.81 | IKBKB (0.67) | IKBKBDYRK2RAF1RPS6KB1MAPK1 | |
| SCHEMBL8128818 | 0.80 | IKBKB (0.67) | IKBKBDYRK2RAF1RPS6KB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117503764-A | Application of curcumin analogue EF24 in preparation of medicines for treating idiopathic pulmonary fibrosis | 中国科学院昆明动物研究所 | 2024-02-06 | — | — | CN | disclosed |
| CN-115232068-B | Compound and preparation method and application thereof | 北京中医药大学 | 2023-09-08 | — | — | CN | disclosed |
| CN-108191751-B | 4-fluorobenzenesulfonyl substituted 3, 5-diarylmethylene-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108997310-B | Asymmetric 3-pyridine substituted 3, 5-diarylmethylene-4-piperidone and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108191750-B | 3, 5-diarylmethylene-N-benzenesulfonyl-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108191742-B | 4-acetamidobenzenesulfonyl-substituted 3, 5-diarylmethylene-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108997311-B | Asymmetric 4-pyridine substituted 3, 5-diarylmethylene-4-piperidone and preparation method thereof | 滨州医学院 | 2023-06-23 | — | — | CN | disclosed |
| CN-115232068-A | Compound and preparation method and application thereof | 北京中医药大学 | 2022-10-25 | — | — | CN | disclosed |
| CN-109053565-B | N-benzenesulfonyl substituted asymmetric pyridine-piperidone compounds and preparation method thereof | 滨州医学院 | 2022-08-12 | — | — | CN | disclosed |
| CN-109053564-B | N-benzenesulfonyl substituted asymmetric piperidone compounds and preparation method thereof | 滨州医学院 | 2022-05-24 | — | — | CN | disclosed |