Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.53 |
| ▸ | KHK | P50053 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30868868 | 0.83 | KDM4E (0.76) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL30343284 | 0.81 | KDM4E (0.71) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL9157755 | 0.81 | KDM4E (0.71) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL9482692 | 0.81 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL1128908 | 0.80 | KDM4E (0.71) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL28357363 | 0.80 | KDM4E (0.69) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL1161820 | 0.79 | KDM4E (0.70) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL29992538 | 0.79 | KDM4E (1.00) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL1905589 | 0.79 | KDM4E (1.00) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL29232559 | 0.79 | KDM4E (0.70) | NPC1RAB9ASMN1; SMN2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999506-A1 | PARP1 INHIBITORS | Astrazeneca AB (SE) | 2022-05-25 | — | — | EP | disclosed |