Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620283 | 0.78 | ALK (0.46) | INSRALKIGF1RPTK2KCNH2 | |
| SCHEMBL29791355 | 0.78 | ALK (0.46) | INSRALKIGF1RPTK2KCNH2 | |
| SCHEMBL30833058 | 0.75 | HRH3 (0.42) | ATRHRH3 | |
| SCHEMBL24620273 | 0.75 | HRH3 (0.42) | ATRHRH3 | |
| SCHEMBL29791351 | 0.69 | EGFR (0.40) | LRRK2INSRALKIGF1RFGFR3 | |
| SCHEMBL26087590 | 0.65 | ALK (0.73) | LRRK2INSRALKIGF1RFGFR3 | |
| SCHEMBL24255480 | 0.65 | ALK (0.56) | LRRK2INSRALKFGFR1 | |
| SCHEMBL15244363 | 0.64 | FGFR3 (0.82) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL15444830 | 0.63 | EGFR (0.57) | INSRALKIGF1RKCNH2 | |
| SCHEMBL21410346 | 0.63 | ALK (0.49) | INSRALKIGF1RCDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4277902-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2023-11-22 | — | — | EP | disclosed |
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |